Collaboration with the Rolston lab
We investigate the effects of sonic stimulation protocols on neural activity in humans.
April 2, 2019
Preprint of sonic neurostimulation in non-human primates
We found that transcranial ultrasound is capable of modulating neurons to the extent of biasing choice behavior of non-human primates. A demonstration of tangible, brain-region-specific effects on behavior of primates constitutes a critical step toward applying this noninvasive neuromodulation method in investigations of how specific neural circuits are involved in specific behaviors or disease signs.
March 25, 2019
Collaboration with the Shcheglovitov lab
We investigate the effects of sonic stimulation protocols on the activity of human neurons.
November 11, 2018
Collaboration with the Vinberg lab
We investigate the effects of sonic stimulation protocols on the activity of retinal cells.
October 12, 2018
Collaboration with Natalya Rapoport
We build on the work of Natalya Rapoport to release drugs from nanoparticle carriers focally using ultrasound.
September 3, 2018
Research paper published in the Journal of Neuroscience
A remote control of cellular excitability in specific regions deep in tissue would constitute a powerful diagnostic and therapeutic tool. Ultrasound has demonstrated this promise, yet how ultrasound stimulates excitable cells has remained elusive. This study shows that ultrasound acts on tissues as a mechanical stimulus and so opens membrane ion channels. This mechanistic insight informs the design of protocols that maximize the stimulatory effects.
February 28, 2018
Review article published in Neurosurgical Focus
The understanding of brain function and the capacity to treat neurological and psychiatric disorders rest on the ability
to intervene in neuronal activity in specific brain circuits. Current methods of neuromodulation incur a tradeoff between spatial focus and the level of invasiveness. Transcranial focused ultrasound (FUS) is emerging as a neuromodulation approach that combines noninvasiveness with focus that can be relatively sharp even in regions deep in the brain. This may enable studies of the causal role of specific brain regions in specific behaviors and behavioral disorders. In addition to causal brain mapping, the spatial focus of FUS opens new avenues for treatments of neurological and psychiatric conditions. This review introduces existing and emerging FUS applications in neuromodulation, discusses the mechanisms of FUS effects on cellular excitability, considers the effects of specific stimulation parameters, and lays out the directions for future work.
December 2, 2017